The beginning of the establishment of the Tugurejo Hospital was to treat leprosy sufferers from various regions in Central Java. The Tugurejo Leprosy Special Hospital was built in 1952 by the Leprosy Eradication Service of Central Java Province. Then in 1968, it developed into the Tugurejo Leprosy Hospital in Semarang. May 31, 2018.

The hospital is classified as a category B hospital (registration code: 3374134) with 257 beds. It is a provincial hospital.