About the 1850s  the policy of the NI authorities concerning syphilis became formulated in regulations  (averting the harmful consequences resulting from prostitution) and a larger budget became available in the fight against venereal diseases. These regulations followed the French system: registration of all prostitutes, compulsory examination, if necessary followed by treatment and the assembling of the women in brothels wherever possible. The regulations became operative in most residencies of Java and in some places in the Outer Provinces.
The effect of all these measures was questionable and so the 1852 regulation was withdrawn in 1874.
The combat against prostitution became a matter of ‘police regulations’ henceforth and entrusted to the local authorities. (Madura).

As ever more health personnel became available ((Dokter djawa and European medical doctors) the opportunity to introduce on a regular base the check of prostitutes on Syphilis was improved. The medical visitation of prostitutes in several towns on Java and Madura was expanded to 394 towns in 1890. At the same time the number of health institutions had grown to 70. Some were at a separate location and some were combined with local prisons. In 1888 a number of 12.705 patients was treated , of whom 11.429 werd discharged as cured, 15 died and 1261 stayed at the hospital. In the Outer Provinces these regulations were at least in the Residential centers with the exemption of Benkoelen, Telok Betong and Menado, as there were no prostitutes documented in these regions. The obligatory medical treatment and visitation occurred in 24 towns. In 18 of these towns 653 women were found  ill; 615 of them were discharged being cured.

The director of Education, health and industry calculated for the period 1878 till 1887 a costing budget of   ƒ 137,047 annually for the Prostitution regulations, with a maximum of ƒ 151.791 and a minimum of ƒ 120,053. The differences per year could be explained from the food budget fluctuations.

About 1890 the hospital at Bangkallan (Madura) was opened. On the first of March 1911 this health establishment was closed together with the other venereal establishments, due to a drastic change in the central policy.

(Gonggryp 1934, p.93: ” Bangkalan was a Regency and District with a capital city of the same name in the Residency Madoera, Government East Java. The capital city used to be the seat of the sultan of Madoera.”)